Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. We do not yet know what causes MIS-C. However, we know that many children with MIS-C had the virus that causes COVID-19 or had been around someone with COVID-19. MIS-C can be serious, even deadly, but most children who were diagnosed with this condition have gotten better with medical care.

COVID-19 vaccination is the best protection against MIS-C for children age 5 and older. Researchers found that vaccination reduced the likelihood of MIS-C in children and adolescents by 91%. Children who are not yet old enough to be vaccinated can take everyday actions to avoid virus that causes COVID-19. Everyone 5 years and older should get a COVID-19 vaccination to help protect against COVID-19.