Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Multisystem inflammatory syndrome in adults (MIS-A) is a similar condition that affects adults and is rarer than MIS-C. Most people with MIS-C or MIS-A had the virus that causes COVID-19 or had been around someone with COVID-19.
People diagnosed with MIS-C or MIS-A should discuss COVID-19 vaccination with their clinical care team. The CDC says the benefits of vaccinating those who have had MIS-C or MIS-A outweigh the theoretical risks as long as 90 days have passed since the diagnosis and the patient has achieved clinical recovery, including return to baseline heart function. COVID-19 vaccination may also be considered for people who had MIS-C or MIS-A and do not meet those criteria, at the discretion of their clinical care team. See the CDC’s recommendations for COVID-19 vaccination and MIS-C and MIS-A.