Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Multisystem inflammatory syndrome in adults (MIS-A) is a similar condition that affects adults and is rarer than MIS-C. Most people with MIS-C or MIS-A had the virus that causes COVID-19 or had been around someone with COVID-19.
People diagnosed with MIS-C or MIS-A should discuss COVID-19 vaccination with their clinical care team. The CDC says the benefits of vaccinating those who have had MIS-C or MIS-A outweigh the theoretical risks as long as 90 days have passed since the diagnosis and the patient has achieved clinical recovery, including return to baseline heart function. See the CDC’s recommendations for COVID-19 vaccination and MIS-C and MIS-A.