Vaccination is our best defense against COVID-19. Clinical trials and observational studies show that all COVID-19 vaccines authorized in the United States are effective at preventing COVID-19, especially severe disease, hospitalization, and death. Some vaccine breakthrough cases are expected, but getting the vaccine significantly reduces the chances of severe illness if an infection does occur.
The CDC recommends eligible people 6 months and older receive an updated, bivalent Pfizer or Moderna vaccine that offers better protection against variants. Some people, like those who are immunocompromised or over 65, are eligible for a second bivalent dose.
The monovalent Novavax booster is available for people 18 and older who completed a primary series, have not received any previous booster dose(s), and are unable or unwilling to receive an mRNA vaccine and would otherwise not receive a booster dose.
The CDC has guidance for everyone 6 months and older based on age and medical condition.