If you received monoclonal antibody (mAb) therapy or convalescent plasma after exposure or infection, you do NOT need to delay your COVID-19 vaccination. Previous CDC guidance stated patients should defer COVID-19 vaccination for 90 days after mAb therapy or convalescent plasma. CDC has revised this guidance based on encouraging evidence that patients who received these treatments still mounted a robust immune response to mRNA vaccination soon after treatment. Getting vaccinated is a priority, and you are able to get vaccinated once your illness is over.
If you are considering receiving pre-exposure prevention monoclonal antibody therapy (before any exposure to someone with COVID-19), it is recommended that you wait at least two weeks after your last COVID-19 vaccination before receiving this treatment. Pre-exposure prevention treatment is not a substitute for vaccination in individuals for whom COVID-19 vaccination is recommended. You should still receive a COVID-19 vaccination if you are eligible and could benefit from the shot.
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