In general, people are considered fully vaccinated two weeks after their second dose in a 2-dose series, such as the Pfizer or Moderna vaccines, or two weeks after a single-dose vaccine, such as Johnson & Johnson’s Janssen vaccine. Check your local COVID-19 Community Level for recommendations on when to wear a mask indoors and additional precautions you can take to protect yourself from COVID-19. If you are immunocompromised or more likely to get very sick from COVID-19, learn more about how to protect yourself. Layered prevention strategies — like staying up to date on vaccines and wearing masks — can help prevent severe illness and reduce the potential for strain on the healthcare system.