The CDC recommends the Moderna, Novavax and Pfizer-BioNTech COVID-19 vaccines for the primary vaccination series. Clinical trials and observational studies show that all COVID-19 vaccines authorized in the United States are effective at preventing COVID-19, especially severe disease, hospitalization, and death.

 The CDC recommends people 5 and older receive an age-appropriate, updated mRNA booster dose if at least 2 months have passed since their primary series or since their most recent booster dose. The monovalent Novavax booster and the Johnson & Johnson primary and booster vaccinations are authorized for people 18 and older in limited situations.

See additional recommendations for people who are moderately to severely immunocompromised.